I was curious, so the following explains why the CDC recommends extending the supply of monkeypox vaccines through changes to the delivery protocol. According to the Melbourne Vaccine Education Centre website, “Intradermal vaccination is the delivery of vaccines into the outer layers of the skin. Most vaccines are delivered via the intramuscular (IM) or subcutaneous (SC) route. The intradermal (ID) route is used for only a small number of vaccines. This method of vaccine delivery requires trained health professionals to ensure safety and efficacy. The skin is a very complex organ that is made up of 3 main layers – the epidermis, dermis and the hypodermis. Each layer has its own anatomy and specific function. The epidermal and dermal layers contain many different cells including the antigen-presenting cells (APC’s) that are thought to play a significant role in mediating an efficient and protective immune response to specific vaccines. The 3 main APC’s are macrophages, dendritic cells and B cells. The APC’s as the name suggests, presents specific antigens to particular cells in the immune system that are responsible in eliciting an immune mediated response that in turn creates memory cells and antibodies. This is how some vaccines are thought to work when given via the ID route with enhanced immunogenicity compared to the IM or SC routes.” Remember: Your skin is the body’s largest organ and the first and most important defense against pathogens. Healthy skin (hair and nails) is a healthy person. You should be paranoid about the way your skin appears. This is your PSA.